| Qualification Round |
| 15-08-1980 |
Budapesti Honved SE - Valletta FC |
8-0 |
 |
 |
| Qualification Round |
| 02-09-1980 |
Valletta FC - Budapesti Honved SE |
0-3 |
|
|
| Round 1 |
| 16-09-1980 |
Linfield FC - FC Nantes |
0-1 |
|
|
| 16-09-1980 |
iBV Vestmannaeyjar - TJ Banik Ostrava OKD |
1-1 |
|
|
| 16-09-1980 |
Viking FK - Red Star Belgrade |
2-3 |
|
|
| 17-09-1980 |
Trabzonspor - Szombierki Bytom |
2-1 |
|
|
| 17-09-1980 |
FK Dinamo - Ajax Amsterdam |
0-2 |
|
|
| 17-09-1980 |
BFC Dynamo - APOEL Nicosia |
3-0 |
|
|
| 17-09-1980 |
Limerick FC - Real Madrid |
1-2 |
|
|
| 17-09-1980 |
CSKA Sofia - Nottingham Forest |
1-0 |
|
|
| 17-09-1980 |
Olympiacos Piraeus - Bayern Munich |
2-4 |
|
|
| 17-09-1980 |
Aberdeen FC - Austria Vienna |
1-0 |
|
|
| 17-09-1980 |
Halmstads BK - Esbjerg fB |
0-0 |
|
|
| 17-09-1980 |
Jeunesse Esch - Spartak Moscow |
0-5 |
|
|
| 17-09-1980 |
Oulun Palloseura - Liverpool FC |
1-1 |
 |
|
| 17-09-1980 |
Club Brugge KV - FC Basel 1893 |
0-1 |
|
|
| 17-09-1980 |
Inter Milan - Universitatea Craiova |
2-0 |
|
|
| 17-09-1980 |
Sporting CP - Budapesti Honved SE |
0-2 |
|
|
| Round 1 |
| 01-10-1980 |
TJ Banik Ostrava OKD - iBV Vestmannaeyjar |
1-0 |
|
|
| 01-10-1980 |
Red Star Belgrade - Viking FK |
4-1 |
|
|
| 01-10-1980 |
Universitatea Craiova - Inter Milan |
1-1 |
|
|
| 01-10-1980 |
Szombierki Bytom - Trabzonspor |
3-0 |
|
|
| 01-10-1980 |
Budapesti Honved SE - Sporting CP |
1-0 |
|
|
| 01-10-1980 |
Spartak Moscow - Jeunesse Esch |
4-0 |
|
|
| 01-10-1980 |
Bayern Munich - Olympiacos Piraeus |
3-0 |
|
|
| 01-10-1980 |
Austria Vienna - Aberdeen FC |
0-0 |
|
|
| 01-10-1980 |
Nottingham Forest - CSKA Sofia |
0-1 |
|
|
| 01-10-1980 |
APOEL Nicosia - BFC Dynamo |
2-1 |
|
|
| 01-10-1980 |
Esbjerg fB - Halmstads BK |
3-2 |
|
|
| 01-10-1980 |
FC Basel 1893 - Club Brugge KV |
4-1 |
|
|
| 01-10-1980 |
Ajax Amsterdam - FK Dinamo |
1-0 |
|
|
| 01-10-1980 |
Liverpool FC - Oulun Palloseura |
10-1 |
|
|
| 01-10-1980 |
Real Madrid - Limerick FC |
5-1 |
|
|
| 01-10-1980 |
FC Nantes - Linfield FC |
2-0 |
|
|
| Last 16 |
| 22-10-1980 |
TJ Banik Ostrava OKD - BFC Dynamo |
0-0 |
|
|
| 22-10-1980 |
Spartak Moscow - Esbjerg fB |
3-0 |
|
|
| 22-10-1980 |
CSKA Sofia - Szombierki Bytom |
4-0 |
|
|
| 22-10-1980 |
Aberdeen FC - Liverpool FC |
0-1 |
|
|
| 22-10-1980 |
Bayern Munich - Ajax Amsterdam |
5-1 |
|
|
| 22-10-1980 |
FC Basel 1893 - Red Star Belgrade |
1-0 |
|
|
| 22-10-1980 |
Real Madrid - Budapesti Honved SE |
1-0 |
|
|
| 22-10-1980 |
FC Nantes - Inter Milan |
1-2 |
|
|
| Last 16 |
| 05-11-1980 |
BFC Dynamo - TJ Banik Ostrava OKD |
1-1 |
|
|
| 05-11-1980 |
Szombierki Bytom - CSKA Sofia |
0-1 |
|
|
| 05-11-1980 |
Red Star Belgrade - FC Basel 1893 |
2-0 |
|
|
| 05-11-1980 |
Budapesti Honved SE - Real Madrid |
0-2 |
|
|
| 05-11-1980 |
Liverpool FC - Aberdeen FC |
4-0 |
|
|
| 05-11-1980 |
Esbjerg fB - Spartak Moscow |
2-0 |
|
|
| 05-11-1980 |
Ajax Amsterdam - Bayern Munich |
2-1 |
|
|
| 05-11-1980 |
Inter Milan - FC Nantes |
1-1 |
|
|
| Quarter Final |
| 04-03-1981 |
Spartak Moscow - Real Madrid |
0-0 |
|
|
| 04-03-1981 |
Liverpool FC - CSKA Sofia |
5-1 |
|
|
| 04-03-1981 |
Bayern Munich - TJ Banik Ostrava OKD |
2-0 |
|
|
| 04-03-1981 |
Inter Milan - Red Star Belgrade |
1-1 |
|
|
| Quarter Final |
| 18-03-1981 |
TJ Banik Ostrava OKD - Bayern Munich |
2-4 |
|
|
| 18-03-1981 |
Red Star Belgrade - Inter Milan |
0-1 |
|
|
| 18-03-1981 |
CSKA Sofia - Liverpool FC |
0-1 |
|
|
| 19-03-1981 |
Real Madrid - Spartak Moscow |
2-0 |
|
|
| Semi Final |
| 08-04-1981 |
Liverpool FC - Bayern Munich |
0-0 |
|
|
| 08-04-1981 |
Real Madrid - Inter Milan |
2-0 |
|
|
| Semi Final |
| 22-04-1981 |
Bayern Munich - Liverpool FC |
1-1 |
|
|
| 22-04-1981 |
Inter Milan - Real Madrid |
1-0 |
|
|
| Final |
| 27-05-1981 |
Liverpool FC - Real Madrid |
1-0 |
|
|
