| Qualification Round |
| 19-08-1980 |
Celtic FC - Diosgyori VTK |
6-0 |
 |
 |
| 20-08-1980 |
Altay SK - SL Benfica |
0-0 |
|
|
| Qualification Round |
| 02-09-1980 |
Diosgyori VTK - Celtic FC |
2-1 |
|
|
| 03-09-1980 |
SL Benfica - Altay SK |
4-0 |
|
|
| Round 1 |
| 16-09-1980 |
Hvidovre IF - Fram Reykjavik |
1-0 |
|
|
| 16-09-1980 |
Valencia CF - AS Monaco |
2-0 |
|
|
| 16-09-1980 |
AS Roma - FC Carl Zeiss Jena |
3-0 |
|
|
| 16-09-1980 |
Newport County - Crusaders FC |
4-0 |
|
|
| 16-09-1980 |
AGS Kastoria - Dinamo Tbilisi |
0-0 |
|
|
| 16-09-1980 |
Slavia Sofia - Legia Warszawa |
3-1 |
|
|
| 16-09-1980 |
Malmo FF - FK Partizani |
1-0 |
|
|
| 16-09-1980 |
GNK Dinamo Zagreb - SL Benfica |
0-0 |
|
|
| 16-09-1980 |
Spora Luxemburg - TJ Sparta CKD Praha |
0-6 |
|
|
| 16-09-1980 |
Omonia Nicosia - Waterschei SV THOR |
1-3 |
|
|
| 16-09-1980 |
Hibernians FC - Waterford United |
1-0 |
|
|
| 16-09-1980 |
Castilla CF - West Ham United |
3-1 |
|
|
| 17-09-1980 |
Ilves Tampere - Feyenoord Rotterdam |
1-3 |
|
|
| 17-09-1980 |
Fortuna Dusseldorf - SV Casino Salzburg |
5-0 |
|
|
| 17-09-1980 |
FC Sion - SK Haugar |
1-1 |
|
|
| 17-09-1980 |
Celtic FC - Politehnica Timisoara |
2-1 |
|
|
| Round 1 |
| 27-09-1980 |
Fram Reykjavik - Hvidovre IF |
0-2 |
|
|
| 01-10-1980 |
SK Haugar - FC Sion |
2-0 |
|
|
| 01-10-1980 |
AS Monaco - Valencia CF |
3-3 |
|
|
| 01-10-1980 |
Crusaders FC - Newport County |
0-0 |
|
|
| 01-10-1980 |
Dinamo Tbilisi - AGS Kastoria |
2-0 |
|
|
| 01-10-1980 |
Legia Warszawa - Slavia Sofia |
1-0 |
|
|
| 01-10-1980 |
FK Partizani - Malmo FF |
0-0 |
|
|
| 01-10-1980 |
SL Benfica - GNK Dinamo Zagreb |
2-0 |
|
|
| 01-10-1980 |
TJ Sparta CKD Praha - Spora Luxemburg |
6-0 |
|
|
| 01-10-1980 |
Waterschei SV THOR - Omonia Nicosia |
4-0 |
|
|
| 01-10-1980 |
Waterford United - Hibernians FC |
4-0 |
|
|
| 01-10-1980 |
West Ham United - Castilla CF |
5-1 AET |
|
|
| 01-10-1980 |
Politehnica Timisoara - Celtic FC |
1-0 |
|
|
| 01-10-1980 |
SV Casino Salzburg - Fortuna Dusseldorf |
0-3 |
|
|
| 01-10-1980 |
FC Carl Zeiss Jena - AS Roma |
4-0 |
|
|
| 01-10-1980 |
Feyenoord Rotterdam - Ilves Tampere |
4-2 |
|
|
| Last 16 |
| 22-10-1980 |
SK Haugar - Newport County |
0-0 |
|
|
| 22-10-1980 |
Waterford United - Dinamo Tbilisi |
0-1 |
|
|
| 22-10-1980 |
Waterschei SV THOR - Fortuna Dusseldorf |
0-0 |
|
|
| 22-10-1980 |
Malmo FF - SL Benfica |
1-0 |
|
|
| 22-10-1980 |
TJ Sparta CKD Praha - Slavia Sofia |
2-0 |
|
|
| 22-10-1980 |
Hvidovre IF - Feyenoord Rotterdam |
1-2 |
|
|
| 22-10-1980 |
West Ham United - Politehnica Timisoara |
4-0 |
|
|
| 22-10-1980 |
FC Carl Zeiss Jena - Valencia CF |
3-1 |
|
|
| Last 16 |
| 05-11-1980 |
Newport County - SK Haugar |
6-0 |
|
|
| 04-11-1980 |
Dinamo Tbilisi - Waterford United |
4-0 |
|
|
| 04-11-1980 |
Fortuna Dusseldorf - Waterschei SV THOR |
1-0 |
|
|
| 04-11-1980 |
SL Benfica - Malmo FF |
2-0 |
|
|
| 04-11-1980 |
Slavia Sofia - TJ Sparta CKD Praha |
3-0 |
|
|
| 04-11-1980 |
Valencia CF - FC Carl Zeiss Jena |
1-0 |
|
|
| 05-11-1980 |
Politehnica Timisoara - West Ham United |
1-0 |
|
|
| 05-11-1980 |
Feyenoord Rotterdam - Hvidovre IF |
1-0 |
|
|
| Quarter Final |
| 03-03-1981 |
West Ham United - Dinamo Tbilisi |
1-4 |
|
|
| 03-03-1981 |
Fortuna Dusseldorf - SL Benfica |
2-2 |
|
|
| 04-03-1981 |
Slavia Sofia - Feyenoord Rotterdam |
3-2 |
|
|
| 04-03-1981 |
FC Carl Zeiss Jena - Newport County |
2-2 |
|
|
| Quarter Final |
| 17-03-1981 |
Dinamo Tbilisi - West Ham United |
0-1 |
|
|
| 17-03-1981 |
SL Benfica - Fortuna Dusseldorf |
1-0 |
|
|
| 18-03-1981 |
Newport County - FC Carl Zeiss Jena |
0-1 |
|
|
| 18-03-1981 |
Feyenoord Rotterdam - Slavia Sofia |
4-0 |
|
|
| Semi Final |
| 08-04-1981 |
Dinamo Tbilisi - Feyenoord Rotterdam |
3-0 |
|
|
| 08-04-1981 |
FC Carl Zeiss Jena - SL Benfica |
2-0 |
|
|
| Semi Final |
| 21-04-1981 |
SL Benfica - FC Carl Zeiss Jena |
1-0 |
|
|
| 22-04-1981 |
Feyenoord Rotterdam - Dinamo Tbilisi |
2-0 |
|
|
| Final |
| 13-05-1981 |
Dinamo Tbilisi - FC Carl Zeiss Jena |
2-1 |
|
|