| Round 1 |
| 15-09-1980 |
IA Akranes - 1 FC Koln |
0-4 |
 |
 |
| 15-09-1980 |
Sliema Wanderers - FC Barcelona |
0-2 |
|
|
| 15-09-1980 |
Ujpesti Dozsa SC - Real Sociedad |
1-1 |
|
|
| 15-09-1980 |
Grasshopper Club Zurich - Kjobenhavns Boldklub |
3-1 |
|
|
| 16-09-1980 |
Kuopion Palloseura - AS Saint etienne |
0-7 |
|
|
| 16-09-1980 |
TJ Bohemians CKD Praha - Sporting Gijon |
3-1 |
|
|
| 16-09-1980 |
TJ Zbrojovka Brno - SK VOEST Linz |
3-1 |
|
|
| 16-09-1980 |
Vasas SC - Boavista FC |
0-2 |
|
|
| 16-09-1980 |
VfB Stuttgart - Pezoporikos Larnaca |
6-0 |
|
|
| 16-09-1980 |
Standard Liege - Steaua Bucharest |
1-1 |
|
|
| 16-09-1980 |
Slask Wroclaw - Dundee United FC |
0-0 |
|
|
| 16-09-1980 |
Shakhtar Donetsk - Eintracht Frankfurt |
1-0 |
|
|
| 16-09-1980 |
RWD Molenbeek - Torino Calcio |
1-2 |
|
|
| 16-09-1980 |
FC Porto - Dundalk FC |
1-0 |
|
|
| 16-09-1980 |
Manchester United - Widzew Lodz |
1-1 |
|
|
| 16-09-1980 |
1 FC Magdeburg - Moss FK |
2-1 |
|
|
| 16-09-1980 |
Dynamo Kyiv - Levski Sofia |
1-1 |
|
|
| 16-09-1980 |
1 FC Kaiserslautern - RSC Anderlecht |
1-0 |
|
|
| 16-09-1980 |
Juventus FC - Panathinaikos FC |
4-0 |
|
|
| 16-09-1980 |
Ipswich Town - Aris Thessaloniki |
5-1 |
|
|
| 16-09-1980 |
Hamburger SV - FK Sarajevo |
4-2 |
|
|
| 16-09-1980 |
IF Elfsborg - St Mirren FC |
1-2 |
|
|
| 16-09-1980 |
FC Sochaux Montbeliard - Servette FC |
2-0 |
|
|
| 17-09-1980 |
SG Dynamo Dresden - FK Napredak Krusevac |
1-0 |
|
|
| 17-09-1980 |
FC Arges Pitesti - FC Utrecht |
0-0 |
|
|
| 17-09-1980 |
Fenerbahce - Beroe Stara Zagora |
0-1 |
|
|
| 17-09-1980 |
LASK - FK Radnicki Nis |
1-2 |
|
|
| 17-09-1980 |
Ballymena United FC - FC Vorwarts Frankfurt Oder |
2-1 |
|
|
| 17-09-1980 |
PSV Eindhoven - Wolverhampton Wanderers |
3-1 |
|
|
| 17-09-1980 |
KSC Lokeren - Dinamo Moscow |
1-1 |
|
|
| 17-09-1980 |
Twente Enschede FC - IFK Goteborg |
5-1 |
|
|
| 17-09-1980 |
AZ 67 Alkmaar - Red Boys Differdange |
6-0 |
|
|
| Round 1 |
| 23-09-1980 |
Pezoporikos Larnaca - VfB Stuttgart |
1-4 |
|
|
| 23-09-1980 |
Kjobenhavns Boldklub - Grasshopper Club Zurich |
2-5 |
|
|
| 30-09-1980 |
Red Boys Differdange - AZ 67 Alkmaar |
0-4 |
|
|
| 01-10-1980 |
AS Saint etienne - Kuopion Palloseura |
7-0 |
|
|
| 01-10-1980 |
Sporting Gijon - TJ Bohemians CKD Praha |
2-1 |
|
|
| 01-10-1980 |
SK VOEST Linz - TJ Zbrojovka Brno |
0-2 |
|
|
| 01-10-1980 |
Boavista FC - Vasas SC |
0-1 |
|
|
| 01-10-1980 |
Steaua Bucharest - Standard Liege |
1-2 |
|
|
| 01-10-1980 |
Dundee United FC - Slask Wroclaw |
7-2 |
|
|
| 01-10-1980 |
Eintracht Frankfurt - Shakhtar Donetsk |
3-0 |
|
|
| 01-10-1980 |
Torino Calcio - RWD Molenbeek |
2-2 AET |
|
|
| 01-10-1980 |
Dundalk FC - FC Porto |
0-0 |
|
|
| 01-10-1980 |
Widzew Lodz - Manchester United |
0-0 |
|
|
| 01-10-1980 |
Moss FK - 1 FC Magdeburg |
2-3 |
|
|
| 01-10-1980 |
St Mirren FC - IF Elfsborg |
0-0 |
|
|
| 01-10-1980 |
Servette FC - FC Sochaux Montbeliard |
2-1 |
|
|
| 01-10-1980 |
1 FC Koln - IA Akranes |
6-0 |
|
|
| 01-10-1980 |
FC Barcelona - Sliema Wanderers |
1-0 |
|
|
| 01-10-1980 |
Real Sociedad - Ujpesti Dozsa SC |
1-0 |
|
|
| 01-10-1980 |
FK Sarajevo - Hamburger SV |
3-3 |
|
|
| 01-10-1980 |
Aris Thessaloniki - Ipswich Town |
3-1 |
|
|
| 01-10-1980 |
Panathinaikos FC - Juventus FC |
4-2 |
|
|
| 01-10-1980 |
RSC Anderlecht - 1 FC Kaiserslautern |
3-2 |
|
|
| 01-10-1980 |
Levski Sofia - Dynamo Kyiv |
0-0 |
|
|
| 01-10-1980 |
FK Napredak Krusevac - SG Dynamo Dresden |
0-1 |
|
|
| 01-10-1980 |
FK Radnicki Nis - LASK |
4-1 |
|
|
| 01-10-1980 |
Dinamo Moscow - KSC Lokeren |
0-1 |
|
|
| 01-10-1980 |
Beroe Stara Zagora - Fenerbahce |
2-1 |
|
|
| 01-10-1980 |
FC Vorwarts Frankfurt Oder - Ballymena United FC |
3-0 |
|
|
| 01-10-1980 |
IFK Goteborg - Twente Enschede FC |
2-0 |
|
|
| 01-10-1980 |
FC Utrecht - FC Arges Pitesti |
2-0 |
|
|
| 01-10-1980 |
Wolverhampton Wanderers - PSV Eindhoven |
1-0 |
|
|
| Round 2 |
| 21-10-1980 |
FC Porto - Grasshopper Club Zurich |
2-0 |
|
|
| 21-10-1980 |
Levski Sofia - AZ 67 Alkmaar |
1-1 |
|
|
| 22-10-1980 |
FC Sochaux Montbeliard - Boavista FC |
2-2 |
|
|
| 22-10-1980 |
St Mirren FC - AS Saint etienne |
0-0 |
|
|
| 22-10-1980 |
Torino Calcio - 1 FC Magdeburg |
3-1 |
|
|
| 22-10-1980 |
Widzew Lodz - Juventus FC |
3-1 |
|
|
| 22-10-1980 |
Dundee United FC - KSC Lokeren |
1-1 |
|
|
| 22-10-1980 |
1 FC Koln - FC Barcelona |
0-1 |
|
|
| 22-10-1980 |
VfB Stuttgart - FC Vorwarts Frankfurt Oder |
5-1 |
|
|
| 22-10-1980 |
1 FC Kaiserslautern - Standard Liege |
1-2 |
|
|
| 22-10-1980 |
TJ Zbrojovka Brno - Real Sociedad |
1-1 |
|
|
| 22-10-1980 |
Ipswich Town - TJ Bohemians CKD Praha |
3-0 |
|
|
| 22-10-1980 |
Beroe Stara Zagora - FK Radnicki Nis |
0-1 |
|
|
| 22-10-1980 |
PSV Eindhoven - Hamburger SV |
1-1 |
|
|
| 22-10-1980 |
Twente Enschede FC - SG Dynamo Dresden |
1-1 |
|
|
| 22-10-1980 |
FC Utrecht - Eintracht Frankfurt |
2-1 |
|
|
| Round 2 |
| 03-11-1980 |
Grasshopper Club Zurich - FC Porto |
3-0 AET |
|
|
| 04-11-1980 |
AZ 67 Alkmaar - Levski Sofia |
5-0 |
|
|
| 04-11-1980 |
Boavista FC - FC Sochaux Montbeliard |
0-1 |
|
|
| 04-11-1980 |
AS Saint etienne - St Mirren FC |
2-0 |
|
|
| 04-11-1980 |
1 FC Magdeburg - Torino Calcio |
1-0 |
|
|
| 04-11-1980 |
Juventus FC - Widzew Lodz |
4-5 on pens |
|
|
| 04-11-1980 |
KSC Lokeren - Dundee United FC |
0-0 |
|
|
| 04-11-1980 |
Hamburger SV - PSV Eindhoven |
2-1 |
|
|
| 04-11-1980 |
FC Barcelona - 1 FC Koln |
0-4 |
|
|
| 04-11-1980 |
FC Vorwarts Frankfurt Oder - VfB Stuttgart |
1-2 |
|
|
| 04-11-1980 |
Standard Liege - 1 FC Kaiserslautern |
2-1 |
|
|
| 04-11-1980 |
Real Sociedad - TJ Zbrojovka Brno |
2-1 |
|
|
| 04-11-1980 |
TJ Bohemians CKD Praha - Ipswich Town |
2-0 |
|
|
| 05-11-1980 |
FK Radnicki Nis - Beroe Stara Zagora |
2-1 |
|
|
| 05-11-1980 |
SG Dynamo Dresden - Twente Enschede FC |
0-0 |
|
|
| 05-11-1980 |
Eintracht Frankfurt - FC Utrecht |
3-1 |
|
|
| Last 16 |
| 25-11-1980 |
Grasshopper Club Zurich - Torino Calcio |
2-1 |
|
|
| 25-11-1980 |
Eintracht Frankfurt - FC Sochaux Montbeliard |
4-2 |
|
|
| 25-11-1980 |
Hamburger SV - AS Saint etienne |
0-5 |
|
|
| 25-11-1980 |
VfB Stuttgart - 1 FC Koln |
3-1 |
|
|
| 25-11-1980 |
KSC Lokeren - Real Sociedad |
1-0 |
|
|
| 25-11-1980 |
Standard Liege - SG Dynamo Dresden |
1-1 |
|
|
| 25-11-1980 |
Ipswich Town - Widzew Lodz |
5-0 |
|
|
| 26-11-1980 |
FK Radnicki Nis - AZ 67 Alkmaar |
2-2 |
|
|
| Last 16 |
| 09-12-1980 |
Torino Calcio - Grasshopper Club Zurich |
3-4 on pens |
|
|
| 09-12-1980 |
FC Sochaux Montbeliard - Eintracht Frankfurt |
2-0 |
|
|
| 09-12-1980 |
AS Saint etienne - Hamburger SV |
1-0 |
|
|
| 09-12-1980 |
1 FC Koln - VfB Stuttgart |
4-1 AET |
|
|
| 09-12-1980 |
Real Sociedad - KSC Lokeren |
2-2 |
|
|
| 09-12-1980 |
SG Dynamo Dresden - Standard Liege |
1-4 |
|
|
| 09-12-1980 |
Widzew Lodz - Ipswich Town |
1-0 |
|
|
| 10-12-1980 |
AZ 67 Alkmaar - FK Radnicki Nis |
5-0 |
|
|
| Quarter Final |
| 03-03-1981 |
Grasshopper Club Zurich - FC Sochaux Montbeliard |
0-0 |
|
|
| 03-03-1981 |
Standard Liege - 1 FC Koln |
0-0 |
|
|
| 03-03-1981 |
AS Saint etienne - Ipswich Town |
1-4 |
|
|
| 04-03-1981 |
AZ 67 Alkmaar - KSC Lokeren |
2-0 |
|
|
| Quarter Final |
| 17-03-1981 |
FC Sochaux Montbeliard - Grasshopper Club Zurich |
2-1 |
|
|
| 17-03-1981 |
1 FC Koln - Standard Liege |
3-2 |
|
|
| 17-03-1981 |
Ipswich Town - AS Saint etienne |
3-1 |
|
|
| 18-03-1981 |
KSC Lokeren - AZ 67 Alkmaar |
1-0 |
|
|
| Semi Final |
| 07-04-1981 |
Ipswich Town - 1 FC Koln |
1-0 |
|
|
| 08-04-1981 |
FC Sochaux Montbeliard - AZ 67 Alkmaar |
1-1 |
|
|
| Semi Final |
| 21-04-1981 |
1 FC Koln - Ipswich Town |
0-1 |
|
|
| 22-04-1981 |
AZ 67 Alkmaar - FC Sochaux Montbeliard |
3-2 |
|
|
| Final |
| 06-05-1981 |
Ipswich Town - AZ 67 Alkmaar |
3-0 |
|
|
| Final |
| 20-05-1981 |
AZ 67 Alkmaar - Ipswich Town |
4-2 |
|
|